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KMID : 0882419930440050636
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Korean Journal of Medicine
1993 Volume.44 No. 5 p.636 ~ p.647
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Effects of High Cholesterol Diet on Lipid and Antioxidant Nutrient Status in Spontaneously Hypertensive Rat
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유언호
류왕성/김현대/유재격/최영선/이희숙/조성희
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Abstract
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ackground ; Hypertension and hypercholesterolemia are two of the most importan risk
factors for atherosclerosis and cardiovascular morbidity. The mechanism by which
hypertension and hypercholesterolemia accelerates atherosclerosis is still uncertain.
Methods ; To investigate the effect of high cholesterol diet on lipid and antioxidant
nutritent status in spontaneously hypertensive rat (SHR), SHRs and Wistar rats were fed
diets with or without 2% cholesterol and 0.3% Na-taurocholate for 6 months.
Results : SHRs became apparently hypertensive after 2 months of feeding, when their
systolic pressure was over 180 mmHg. Heart weight-to-body weight rations of SHRs were
significantly higher than those of Wistar rats. Levels of serum total cholesterol were
increased about two-folds and those of liver, ten-folds in both SHRs and Wistar rats by
dietary cholesterol. Serum HDL-cholesterol of SHRs were significantly lower than those of
Wistar rats and HDL-/total cholesterol rations tended to be decreased by dietary cholesterol.
Serum TG levels were not changed, but liver levels increased by dietary cholesterol and
lower in SHRs. Serum TBARS levels were higher in SHRs, but little changed by dietary
cholesterol. Liver levels appeared to be higher in SHRs and cholesterol groups. Serum and
liver vitamin E levels were lower in SHR. Serum vitamin A levels were little changed, but
liver contents were somewhat decreased in SHRs and remarkably reduced by dietary
cholesterol.
Conclustion : It is concluded that hypertension and hypercholesterolemia, individually, result
in accumulation of lipid peroxide as well as consumption of body tocopherol and retinol,
which can be further augmented by coexistence of two abnormal conditions.
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KEYWORD
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